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  • RESEARCH

    How a protein called Epac controls blood vessel diameter

    University of Liverpool | Professor Caroline Dart

    Dr Caroline Dart and colleagues at the University of Liverpool are studying how a protein called Epac controls blood vessel diameter. Blood vessels constantly change their diameter to match blood flow to the oxygen needs of tissues. These a...

  • RESEARCH

    Developing whole heart MRI

    Imperial College London | Dr Peter Gatehouse

    Coronary artery disease and some inherited heart muscle diseases cause patients to experience symptoms of breathlessness, fatigue and chest pain, because of a restricted blood supply to the heart muscle. A relatively new method for measurin...

  • RESEARCH

    Uromodulin – a good target for high blood pressure?

    University of Glasgow | Professor Sandosh Padmanabhan

    In the UK, around a third of all adults have high blood pressure, putting them at higher risk of heart and circulatory disease, and people with kidney problems often develop high blood pressure and heart disease such as heart failure, strok...

  • Socialising could reverse frailty in older people

    Socialising could reverse frailty in older people

  • RESEARCH

    Revealing how our genes influence high blood pressure

    University of Manchester | Professor Maciej Tomaszewski

    DNA methylation is a chemical modification of DNA that switches off genes. It is an important contributor to heart and circulatory health and diseases. In this project, Professor Tomaszewski and his team will assess DNA methylation in the ...

  • RESEARCH

    Building 3D models of ion channels for drug discovery

    University of Leeds | Dr Robin Bon

    Ion channels are transporters that allow substances in and out of cells. Ion channels formed of TRPC1, TRPC4 and TRPC5 proteins are involved in several heart and circulatory diseases. It is very important to understand, in enough detail, th...

  • RESEARCH

    How do genetic faults cause lymphoedema?

    St George's, University of London | Dr Pia Ostergaard

    Supervised by Dr Pia Ostergaard, this PhD student is studying how genetic faults can lead to primary lymphoedema, a lifelong, often disabling condition affecting the lymphatic system. The lymphatic system is a network of vessels that car...

  • RESEARCH

    Understanding genetic errors that affect myosin in cardiomyopathy

    University of Kent | Professor Michael Geeves

    Individuals with inherited genetic errors in heart muscle proteins are at risk of sudden death at any age. This is because the error leads to two major types of heart disease: a thickened heart wall (called hypertrophic cardiomyopathy); or ...

  • RESEARCH

    Are histone proteins involved in heart complications in sepsis?

    University of Liverpool | Dr Guozheng Wang

    Sepsis and septic shock are the main cause of death in patients in intensive care. Patients with sepsis, a widespread infection, often die because their blood pressure and heart function drop significantly, and they can’t supply enough bloo...