Towards understanding cAMP signalling in the vasculature: spatio-temporal activation of PKA and Epac by physiological vasodilators
Dr Caroline Dart and colleagues at the University of Liverpool are studying how a protein called Epac controls blood vessel diameter. Blood vessels constantly change their diameter to match blood flow to the oxygen needs of tissues. These adjustments are made by the contraction and relaxation of muscle cells within the blood vessel wall. The researchers have found that Epac regulates the relaxation of arterial muscle cells although it is unclear exactly how Epac works. This research will further our knowledge of the processes involved in the regulation of blood vessel diameter. This is important not only to understand the way the body regulates blood flow, but also for development of new drugs to treat diseases such as diabetes and high blood pressure (hypertension).
Project details
| Grant amount | £197,568 |
|---|---|
| Grant type | Project Grants |
| Application type | Project Grant |
| Start Date | 01 March 2015 |
| Duration | 3 years |
| Reference | PG/14/55/30973 |
| Status | Complete |
