Epigenetic mechanisms of blood pressure regulation and human hypertension – genome-wide methylation analysis of the human kidney
DNA methylation is a chemical modification of DNA that switches off genes. It is an important contributor to heart and circulatory health and diseases. In this project, Professor Tomaszewski and his team will assess DNA methylation in the kidneys (an important organ for the regulation of blood pressure) of healthy people and people with high blood pressure. They will look at the extent of DNA methylation in the human kidney and determine how these methylations affect different genes known to be involved in controlling blood pressure. The study will improve our understanding of high how blood pressure is controlled and could lead to new ways to diagnose and treat those most at risk from the condition.
Project details
| Grant amount | £308,280 |
|---|---|
| Grant type | Project Grants |
| Application type | Project Grant |
| Start Date | 01 April 2019 |
| Duration | 3 years |
| Reference | PG/19/16/34270 |
| Status | In Progress |
