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RESEARCH
From bug to drug: engineering new heart drugs from tick salivaUniversity of Oxford | Professor Shoumo Bhattacharya
Inflammation plays a role in several heart and circulatory diseases, including myocarditis – inflammation of the heart tissue. It is a very serious condition, which has a poor prognosis and no effective treatment. BHF Professor Shoumo Bhatt...
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RESEARCH
What triggers an aneurysm to get bigger, and can we stop it?University of Leeds | Dr Marc Bailey
Abdominal aortic aneurysm (AAA) is a ballooning of the main blood vessel in the body, the aorta. AAAs tend to grow over time and eventually may rupture, which can be fatal. At the moment, the only treatment is surgery if the aneurysm is lar...
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How inequalities contribute to heart and circulatory diseases
Data has been brought together across prevention, treatment and outcomes by levels of deprivation in England, outlining health inequalities.
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RESEARCH
Swapping the heart’s energy source to treat heart failureUniversity of Oxford | Dr Oliver Rider
Regardless of cause, most heart diseases ultimately result in the heart being unable to pump out as much blood as a normal heart can, because it can’t contract as forcefully. To contract, the heart needs an energy source called ATP, and it’...
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RESEARCH
How do heart muscle proteins change shape when the heart beats?University of Bristol | Dr Danielle Paul
Proteins that make up heart muscle are arranged into structures called filaments. There are two types of filament: thick and thin. A protein called troponin is one of the main components of the thin filament and acts like a switch that turn...
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RESEARCH
Understanding how oxidation of a protein called PKGI-alpha regulates the heartbeatUniversity of Manchester | Dr Luigi Venetucci
Each heartbeat consists of two phases: systole and diastole. During systole, heart muscle cells – cardiomyocytes – in the lower chambers of the heart contract (shorten) to pump blood out of the heart. During diastole, these lower chamber ca...
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RESEARCH
Understanding the heart’s protective mechanisms to prevent heart failureKing's College London | Professor Ajay Shah
The focus of most heart failure treatments is to prevent further degeneration of the heart muscle, a process called adverse cardiac remodelling. There is, however, another type of remodelling that is good for the heart. Adaptive remodelling...
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RESEARCH
Can we target the cancer-like growth of cells to treat pulmonary arterial hypertension?Imperial College London | Professor Lan Zhao
Pulmonary arterial hypertension (PAH) is a life-threatening disease with no cure where high blood pressure in the lungs puts strain on the right side of the heart and leads to heart failure. PAH involves the over-production of cells in the ...
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