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RESEARCH
Investigating if MRI scanning can pick up prenatal brain defects in congenital heart diseaseUniversity of Sheffield | Professor Paul Griffiths
Structural problems in the developing heart (congenital heart disease) are amongst the most common birth defects in the UK. Many children with heart defects also have problems with the development of their brain, potentially causing difficu...
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RESEARCH
How do heart muscle proteins change shape when the heart beats?University of Bristol | Dr Danielle Paul
Proteins that make up heart muscle are arranged into structures called filaments. There are two types of filament: thick and thin. A protein called troponin is one of the main components of the thin filament and acts like a switch that turn...
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RESEARCH
Preventing long-term side effects from stent surgeryKing's College London | Professor Bijan Modarai
Aneurysms (swellings) in the aorta, the body’s main blood vessel, are often treated with stents. Sometimes stents can block branches of blood vessels supplying blood to the spinal cord, and in 10% of these cases, this interruption in blood-...
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RESEARCH
Do pre-hospital electrocardiograms increase heart attack survival, and are they used enough?Kingston University London | Professor Tom Quinn
When someone has a suspected heart attack, the ambulance service can test the electrical activity of a person’s the heart to determine the best treatment for them. In a previous project, Professor Tom Quinn and colleagues showed that peo...
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How inequalities contribute to heart and circulatory diseases
Data has been brought together across prevention, treatment and outcomes by levels of deprivation in England, outlining health inequalities.
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RESEARCH
Understanding how oxidation of a protein called PKGI-alpha regulates the heartbeatUniversity of Manchester | Dr Luigi Venetucci
Each heartbeat consists of two phases: systole and diastole. During systole, heart muscle cells – cardiomyocytes – in the lower chambers of the heart contract (shorten) to pump blood out of the heart. During diastole, these lower chamber ca...
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RESEARCH
Understanding the heart’s protective mechanisms to prevent heart failureKing's College London | Professor Ajay Shah
The focus of most heart failure treatments is to prevent further degeneration of the heart muscle, a process called adverse cardiac remodelling. There is, however, another type of remodelling that is good for the heart. Adaptive remodelling...
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RESEARCH
Could ultra-low-dose aspirin reduce side effects and prevent heart attacks?University of Sheffield | Professor Robert Storey
Sheffield researchers will test whether twice-daily low-dose aspirin could be safer than a once-daily standard dose for heart attack prevention. A heart attack occurs when a blood clot blocks a coronary artery feeding the heart. People who...
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RESEARCH
Can we target the cancer-like growth of cells to treat pulmonary arterial hypertension?Imperial College London | Professor Lan Zhao
Pulmonary arterial hypertension (PAH) is a life-threatening disease with no cure where high blood pressure in the lungs puts strain on the right side of the heart and leads to heart failure. PAH involves the over-production of cells in the ...
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RESEARCH
What do bright spots in pregnancy scans tell us about children’s hearts?Cardiff University | Dr Lisa Hurt
Each day in the UK, 12 babies are diagnosed with a heart defect that occurs as the baby develops in the womb. Pregnant women have an ultrasound scan when they are about 20 weeks pregnant, and nearly half of all serious heart defects are det...