Impact of mast cells on neutrophil-pericyte interactions & neutrophil effector functions: Role of IL-17A?
Inflammation is an essential part of the body’s defence system against viruses and bacteria. It is also an underlying cause of many heart and circulatory conditions like atherosclerosis. Atherosclerosis is the build-up of fatty substances in the walls of arteries and it is the major cause of heart attacks. Inflammation involves a number of types of immune cells working together. In this project, researchers will focus on mast cells, a type of immune cell found near blood vessels. Once triggered, mast cells put out a signal to gather more immune cells to the site and help them to travel in and out of blood vessels. Professor Sussan Nourshargh and her team want to unravel the role of mast cells in heart and circulatory disease. Her team will use cutting-edge intravital microscopy, to observe biological processes taking place in live cells or animals in minute detail. They will look at how mast cells interact with other cells to promote inflammation. The project will improve our understanding of how inflammation is involved in heart and circulatory diseases and might ultimately lead to the identification of new therapeutic targets for treating these conditions.
Project details
| Grant amount | £255,670 |
|---|---|
| Grant type | Project Grants |
| Application type | Project Grant |
| Start Date | 01 July 2018 |
| Duration | 3 years |
| Reference | PG/17/85/33395 |
| Status | In Progress |
