Search
There are 3739 result(s) for coronary disease mortality
-
RESEARCH
New drugs to break the cycle of heart scarringUniversity of Bristol | Dr Mark Bond
The build-up of scar tissue in the heart (fibrosis) is a key process that contributes to heart failure. It is caused by an increased number of cells called fibroblasts, which lay together to form scar tissue. The result is that the heart wa...
-
RESEARCH
Tracing early origins of heart development in the embryo to inform stem cell therapiesUniversity of Oxford | Professor Catherine Porcher
Development of a fully formed heart and circulation in the embryo requires the precise allocation of cells to the right place at the right time. Our understanding of these processes has improved in recent decades but the very earliest stage...
-
RESEARCH
How SUMO wrestles heart injury after a heart attackUniversity of Bristol | Professor Jeremy Henley
Dr Jeremy Henley and colleagues at the University of Bristol have been awarded a grant to investigate how a protein called SUMO can help protect the heart from injury. The SUMO protein is attached to a specific protein in mitochondria, whic...
-
RESEARCH
A protein WISP-1 may reduce the risk of aneurysm formationUniversity of Bristol | Professor Sarah Jane George
Professor Sarah Jane George and colleagues at the University of Bristol have been awarded a 3-year grant to demonstrate the role of a protein called WISP-1 in reducing the risk of aneurysm formation. An aneurysm is a localized, balloon-...
-
RESEARCH
Improving patient outcome after transcatheter aortic valve replacement surgery for aortic stenosisUniversity College London | Professor Gaetano Burriesci
Dr Gaetano Burriesci has been awarded a PhD studentship to work out how to improve patient outcome following transcatheter aortic valve implantation (TAVI), an operation where a new valve is manoeuvred up the femoral artery and inserted ins...
-
RESEARCH
How do potentially deadly aneurysms grow?University of Leicester | Professor Matthew Bown
<p>An abdominal aortic aneurysm (AAA) is a balloon-like swelling of the aorta, the body’s main blood vessel. If AAAs become large and burst, they can cause internal bleeding and sudden death. Surgery to repair AAA is risky, but doctor...
-
RESEARCH
Predicting the risk of serious complications in hypertrophic cardiomyopathyUniversity of Oxford | Professor Dr Stefan Piechnik
Dr Stefan Piechnik and his team at the University of Oxford are developing new ways to predict which people with an inherited heart condition, called hypertrophic cardiomyopathy (HCM), are more at risk of complications, so doctors can treat...
-
RESEARCH
Preventing blood vessel damage with stem cellsUniversity of Birmingham | Professor Gerard Nash
Mesenchymal stem cells (MSC) are a type of stem cell that can be extracted from human tissue and grown to large numbers in the laboratory. Professor Gerard Nash and his team at the University of Birmingham have been studying MSCs and believ...
-
RESEARCH
A sugar coated solution to stop blood vessel leakinessUniversity of Bristol | Dr Rebecca Foster
Cells that line the blood vessels (endothelial cells) are coated with a protective layer of sugars, called the glycocalyx, which helps the blood vessels to function normally. In health, vascular endothelial growth factor-A (VEGFA) is an im...
-
RESEARCH
Developing a new model simulating the heartbeatImperial College London | Professor Cesare M N Terracciano
Supervised by Professor Cesare Terracciano, an MBPhD student is developing a new model that simulates the heartbeat in the laboratory so it can be used in research to bring regenerative medicine to the clinic. The ability to make cardia...