Role of WISP-1 (CCN4) in aneurysms
Professor Sarah Jane George and colleagues at the University of Bristol have been awarded a 3-year grant to demonstrate the role of a protein called WISP-1 in reducing the risk of aneurysm formation. An aneurysm is a localized, balloon-like bulge in the wall of a blood vessel which is caused by weakening of the vessel wall, in part due to death of cells and inflammation. As aneurysms grow in size, there is an increased risk of rupture, resulting in disability or even sudden death. Recent research has shown that the protein WISP-1 reduces cell death, inflammation and weakening of the vessel wall, but is barely present in human aneurysms, suggesting it may have a role in aneurysm formation. This research will help improve understanding of the role of WISP-1 in aneurysm formation and rupture. Screening programmes in the UK are performed to detect aneurysms in >65 year olds but currently there are no effective drug treatments for aneurysm. Dr George’s research may enable the development of a new drug which mimics the effect of WISP-1 and reduces cell death, inflammation and weakening of blood vessel walls to decrease the risk of developing an aneurysm.
Project details
| Grant amount | £139,577 |
|---|---|
| Grant type | Project Grants |
| Application type | Project Grant |
| Start Date | 01 January 2015 |
| Duration | 3 years |
| Reference | PG/14/67/31030 |
| Status | Complete |
