Tracing mesoderm-derived lineages through single cell analysis and fate mapping studies
Development of a fully formed heart and circulation in the embryo requires the precise allocation of cells to the right place at the right time. Our understanding of these processes has improved in recent decades but the very earliest stages of development – when cells first start receiving instructions to begin forming the heart – are still not entirely clear. In this project, Professor Catherine Porcher and her team will aim to trace heart development back to its earliest origins in the mouse embryo. This includes intricate work to label and snapshot single cells in the heart at multiple points during development, identifying the eventual position and purpose of each one. This work will contribute to our expanding understanding of heart development, and how it can go wrong in babies, causing congenital heart disease. By re-creating heart development in the lab, we may be able to generate tissues to use in new regenerative medicine approaches to treating heart and circulatory disease.
Project details
| Grant amount | £313,337 |
|---|---|
| Grant type | Project Grants |
| Application type | Project Grant |
| Start Date | 02 January 2018 |
| Duration | 3 years |
| Reference | PG/16/106/32669 |
| Status | In Progress |
