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  • RESEARCH

    How intensively should we treat blood pressure in people with disease of the small blood vessels in the brain?

    University of Cambridge | Professor Hugh Markus

    Disease of the small blood vessels in the brain is an important cause of stroke and is the most common cause of cognitive impairment and dementia. High blood pressure is the major factor causing small vessel disease of the brain. We know t...

  • RESEARCH

    Can Wnt proteins stop atherosclerotic plaques becoming unstable and rupturing?

    University of Bristol | Professor Sarah Jane George

    Professor Sarah Jane George and her team at the University of Bristol have discovered that a family of proteins called Wnt may be important in keeping fatty atherosclerotic plaques stable. When fatty material builds up on the inner lining o...

  • RESEARCH

    New magnetic resonance technology for the University of Oxford

    University of Oxford | Professor Damian Tyler

    Heart failure is a debilitating condition and can cause breathlessness, making it almost impossible for patients to do even simple exercise such as walking up stairs. During heart failure, changes occur in heart muscle. BHF-funded scient...

  • RESEARCH

    Why are endurance athletes more prone to abnormal heart rhythms?

    University of Manchester | Professor Mark R Boyett

    Our heart requires an electrical signal to beat correctly. When this signal breaks down, disturbances in the heart beat called arrhythmias occur. Arrhythmias can cause serious health problems and even sudden death. We know that athletes who...

  • RESEARCH

    Developing cell therapy to prevent heart transplant rejection

    King's College London | Professor Ajay Shah

    When someone’s heart is failing, a transplant is sometimes the only treatment option. However, the new heart can be rejected by the body’s immune response, even when medicines are taken to try and prevent this. Professor Shah and his team...

  • RESEARCH

    Why are failing hearts more susceptible to atrial fibrillation?

    University of Manchester | Dr Katharine Dibb

    BHF-funded researchers in Manchester are investigating what underlies the link between heart failure and atrial fibrillation. People with heart failure often develop a common heart rhythm problem, called atrial fibrillation, which signif...

  • RESEARCH

    Developing and testing new heart valves for people with aortic stenosis

    University of Cambridge | Professor Geoffrey Moggridge

    Dr Geoffrey Moggridge and his colleagues at the University of Cambridge are developing new heart valves that could help more people with aortic stenosis, or AS. In AS the valve separating the heart and the aorta, the main artery supplyi...

  • RESEARCH

    How cancer treatment is linked to heart disease

    University of Strathclyde | Professor Robin Plevin

    Cancer treatment can involve killing cancer cells with radiation. Radiation treatment is often successful but irradiation can also damage blood vessels, including the coronary arteries, and people can go on to develop heart disease. The go...

  • RESEARCH

    Exploring the potential of a new heart-protecting drug

    King's College London | Professor Susan Brain

    Calcitonin gene-related peptide (CGRP) is a short protein, produced by certain types of nerves, that relaxes blood vessels. Several decades ago it was realised that CGRP might be beneficial for treating heart and circulatory diseases, but i...

  • RESEARCH

    A world-leading centre for developmental and regenerative medicine research

    University of Oxford | Professor Paul Riley

    The BHF is helping the University of Oxford bring together developmental biology and regenerative medicine in a single institute by contributing £5 million towards a new Institute of Developmental and Regenerative Medicine (IDRM). The new b...