Finding potential drugs to control blood vessel function

Understanding the molecular pharmacology of vascular calcium-activated chloride channels (Miss Ria Dinsdale)

Calcium-activated chloride channels (CaCCs) are one of a family of important molecules called ion channels, which are present on the surface of all cells. They are involved in several physiological processes, including the expansion and contraction of blood vessels. Compared to other ion channels, there is little known about CaCCs, and yet they could potentially be useful targets for treating conditions such as high blood pressure, low blood pressure and shock. Recently, a gene that is important for the production of CaCCs - called TMEM16A - was identified and provides new insights into its function. This PhD studentship, supervised by Dr Paolo Tammaro, seeks to build on this discovery by defining the properties of CaCCs in blood vessels, and how they can be targeted with drugs. The student will first generate a computer model of the CaCC structure, using a similar ion channel in fungi as a model. This will allow the researchers to conduct other studies, determining exactly where compounds attach to the channel, and screening potential drugs to see if they activate it. The hope is that the computer model will reveal potential drugs that they can test on isolated arteries to see whether they control blood vessel function. If successful, the project may lead to new drugs which could benefit people with a range of blood vessel disorders.