Angiotensin-II receptor blockers (ARBs) are medicines used to treat high blood pressure, a heart attack, heart failure and kidney disease. They help your blood vessels to widen and relax which lowers your blood pressure and increases the amount of blood flowing to your heart.
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About ARBs
What are ARBs?
Angiotensin-II receptor blockers (ARBs) are medicines that help your blood vessels to widen and relax. This helps lower your blood pressure and increases the amount of blood flowing to your heart.
You may be prescribed an ARB if you have previously tried an ACE inhibitor and it gave you side effects.
You may also be given other medicines to take for your condition. For example, if you have high blood pressure you may also take a calcium channel blocker.
You may hear ARBs being called angiotensin-II receptor antagonists.
How do ARBs work?
ARBs block the effects of a hormone called angiotensin II.
This hormone increases your blood pressure by:
Making your blood vessels contract so they become narrower and your blood has less space to flow.
Making your body hold onto more water in your blood.
By reducing the hormone, ARBs make your blood vessels widen and relax, so your blood has more space to flow through.
This helps lower your blood pressure, making it easier for your heart to pump blood around your body, and helps to improve blood flow to your heart.
Types of ARBs
What are the different types of ARBs?
There are different types of ARBs. Some common types include:
losartan
valsartan
candesartan
irbesartan.
Find out more about these medicines on the NHS website.
You will usually be given a low dose first and it will be increased if it’s needed.
Side effects
What are the side effects?
All medicines have potential side effects, but most people will not experience side effects.
Side effects from this medicine may include:
dizziness (usually due to low blood pressure)
headache
feeling weak, tired, lacking energy and strength.
Different medicines will have different side effects. If you’ve started taking ARBs recently it’s worth bearing in mind that symptoms with any new medicine may improve over time or even disappear.
After you start ARBs, you’ll need regular blood tests to check how well your kidneys are working. In some cases, they can upset your kidneys.
When should I get help?
Talk to your doctor if you’re having side effects. They can help you manage them or look at other options with you.
It’s important not to stop taking your medicine without speaking to a healthcare professional first.
How and when to take them
How do I take this medicine?
Most people will take an ARB once a day.
Taking them at the same time each day can help you to remember to take them.
Your doctor will give you more information about the type of ARB they’re giving you and how often you should take it.
If you forget to take your medicine and:
It's only a short time after your usual dose, take it as soon as you remember. Then take your next dose at the usual time.
It’s nearly time for your next dose, do not take the one you missed. Wait and take your next dose at the usual time.
How long do I take it for?
Most people with high blood pressure will need to take medicines to lower their blood pressure long-term.
Your blood pressure will be checked regularly to make sure it’s under control. If your blood pressure is not under control, your doctor may recommend increasing the dose of your medicine or trying an alternative or additional medicine.
It’s important not to stop taking your medicine without speaking to a healthcare professional first.
Things to avoid if you’re taking ARBs
It’s important to check with your doctor or pharmacist before taking any other medicine while you’re taking an ARB.
There are certain foods and over-the-counter medicines you may need to limit or avoid if you’re taking an ARB. This is because they can stop your medicine from working properly or increase the risk of side effects.
This includes:
salt substitutes that contain potassium
potassium supplements
NSAID medicines, like ibuprofen
grapefruit and grapefruit juice (only if you’re taking losartan).
You should not take ARBs if you’re pregnant or breastfeeding. If you’re currently taking an ARB and you’re planning to get pregnant or you become pregnant, speak to your doctor.
Get help with ARB medicines
Our cardiac nurses can help answer your questions on ARBs. Call, email or live chat with them on our Heart Helpline.
This booklet can help you and your loved ones understand what high blood pressure is and how to make healthier changes to look after your heart health.
To find out more, or to support British Heart Foundation’s work, please visit www.bhf.org.uk. You can speak to one of our cardiac nurses by calling our helpline on 0808 802 1234 (freephone), Monday to Friday, 9am to 5pm. For general customer service enquiries, please call 0300 330 3322, Monday to Friday, 9am to 5pm.
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