Air pollution linked to heart remodelling

3 August 2018        

Category: Research

Researchers part-funded by us have found that people exposed to air pollution levels well within UK guidelines have changes in the structure of the heart, similar to those seen in the early stages of heart failure.

Busy traffic on the motorway at dusk

A team of scientists, led from Queen Mary University of London by Professor Steffen Petersen, studied data from around 4,000 participants in the UK Biobank study. Volunteers provided a range of personal information, including their lifestyles, health record and details on where they have lived. Participants also had blood tests and health scans.

Even though most participants lived outside major UK cities, there was a clear association between those who lived near loud, busy roads, and were exposed to nitrogen dioxide (NO2) or PM2.5 - small particles of air pollution – and the development of larger right and left ventricles in the heart. The ventricles are important pumping chambers in the heart and, although these participants were healthy and had no symptoms, similar heart remodelling is seen in the early stages of heart failure.

Higher exposures to the pollutants were linked to more significant changes in the structure of the heart. For every 1 extra µg per cubic metre of PM2.5 and for every 10 extra µg per cubic of NO2, the heart enlarges by approximately 1% .

Air pollution is now the largest environmental risk factor linked to deaths in England. Globally, coronary heart disease and stroke account for approximately six in ten (58%) deaths related to outdoor air pollution. This research could help explain exactly how and why air pollution affects the heart.

Air pollution exposure within UK guidelines still linked to serious heart changes

In the study, average annual exposures to PM2.5 (8-12µg per cubic metre) were well within UK guidelines (25µg per cubic metre), although they were approaching or past World Health Organisation (WHO) guidelines (10µg per cubic metre). The WHO has said that there are no safe limits of PM2.5. The participants’ average exposure to NO2 (10-50µg per cubic metre) was approaching and above the equal WHO and UK annual average guidelines (40µg per cubic metre).

Ahead of the Government’s consultation on their draft Clean Air Strategy closing on 14 August 2018, we want to ensure the public’s heart and circulatory health is at the centre of discussions.

The Strategy commits to halving the number of people in the UK living in areas where PM2.5 levels exceed WHO guidelines (10 µg per cubic metre) by 2025, but ultimately we want to see this action go further to reduce the health impacts of toxic air as quickly as possible. 

Dr Nay Aung who led the data analysis from Queen Mary University of London said:

“Although our study was observational and hasn’t yet shown a causal link, we saw significant changes in the heart, even at relatively low levels of air pollution exposure. Our future studies will include data from those living in inner cities like Central Manchester and London, using more in-depth measurements of heart function, and we would expect the findings to be even more pronounced and clinically important.

Mya Steer, 19, lives just outside Bristol, she was diagnosed with an inherited heart condition, arrhythmogenic right ventricular cardiomyopathy (ARVC) just after her 18th birthday:
“My heart condition means that I often struggle to breathe anyway and air pollution makes me feel much worse – it’s pretty instant. This research just goes to show that pollution is affecting us all, whether we live in busy cities or more rural areas where we might feel ‘protected’ from pollution.

“There is no safe limit for air pollution for me, or for anyone who is concerned about their heart health – we all need the Government to do more.”

Professor Jeremy Pearson, our Associate Medical Director, said:
“We can’t expect people to move home to avoid air pollution – Government and public bodies must be acting right now to make all areas safe and protect the population from these harms.

“What is particularly worrying is that the levels of air pollution, particularly PM2.5, at which this study saw people with heart remodelling are not even deemed particularly high by the UK Government – this is why we are calling for the WHO guidelines to be adopted. They are less than half of UK legal limits and while we know there are no safe limits for some forms of air pollution, we believe this is a crucial step in protecting the nation’s heart health.

“Having these targets in law will also help to improve the lives of those currently living with heart and circulatory diseases, as we know they are particularly affected by air pollution.”

This research was a collaboration between Queen Mary University of London and the University of Oxford.

The BHF is working to make sure the Government introduces our air pollution policy recommendations, which aim to reduce the public's health risk from air pollution. 

How can I protect myself from air pollution?