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RESEARCH
Finding out if protein called Brn-3b controls aortic stiffnessUniversity College London | Dr Vishwanie Budhram-Mahadeo
Dr Vishwanie Budhram Mahadeo from University College London is studying a protein called Brn-3b, to find out if this protein could hold the key to preventing stiffness of the heart’s major artery. The aorta is a large, elastic blood ves...
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RESEARCH
Using artificial intelligence to predict the underlying causes of high blood pressureUniversity of Manchester | Professor Maciej Tomaszewski
High blood pressure (hypertension) is a major cause of heart attacks and strokes. Studies of the human genome have identified over a thousand differences between people’s DNA (genetic variants) that are associated with blood pressure. T...
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RESEARCH
How are LXRs and IRF8 involved in the development of atherosclerosis?University College London | Dr Ines Pineda Torra
This study will investigate the relationship between Liver X receptors (LXRs) and another key protein, called IRF8, which plays a critical role in the development of new immune cells during inflammation. LXRs are cholesterol ‘sensors’ in th...
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RESEARCH
Dietary fat affects blood vessel function in high blood pressureUniversity of Edinburgh | Professor Michael Shipston
People with high blood pressure are at higher risk of heart and circulatory disease. High blood pressure can arise as a result of blood vessels losing their elasticity, meaning that blood vessels cannot expand and contract as effectively to...
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RESEARCH
A stem cell that promotes new blood vessel growthQueen's University Belfast | Professor David Grieve
Diseases that are caused by reduced blood flow, such as heart attacks, strokes and some forms of blindness, affect millions of people each year and are major causes of ill health and death. Dr David Grieve from Queen’s University Belfast is...
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RESEARCH
Deciphering a surprising discovery in type 2 diabetesUniversity of Leeds | Dr Piruthivi Sukumar
Type 2 diabetes is a major global challenge. The condition can have a wide range of health consequences, including causing damage to blood vessels and raising the risk of a heart attack. Type 2 diabetes occurs when the body’s cells can’t re...
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RESEARCH
Working out how platelets cause harmful blood clotsUniversity of Reading | Dr Christopher Jones
Dr Christopher Jones and his team at the University of Reading are studying how small blood cells called platelets clump together to form clots when blood vessels become damaged. Large clots in the heart’s blood vessels can cause heart atta...
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RESEARCH
Why do we like salt so much, and how does it cause high blood pressure?University of Edinburgh | Professor Matthew Bailey
High blood pressure is a major risk factor for heart and circulatory disease and it affects millions of people in the UK. Having too much salt in our diet can lead to high blood pressure, so it’s important that we try to limit our int...
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RESEARCH
Following the TRAIL to pulmonary arterial hypertensionUniversity of Sheffield | Professor Allan Lawrie
In this Senior Fellowship, Dr Lawrie, based at the University of Sheffield, will investigate the role of two proteins TRAIL and OPG in pulmonary arterial hypertension (PAH), a rare but devastating condition where high blood pressure in the ...