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RESEARCH
Is QKI the missing link causing the damaging effects of diabetes on our blood vessels?Queen's University Belfast | Dr Andriana Margariti
It is estimated that by 2045 there will be 629 million people with diabetes across the globe. Diabetes is a major cause of damage to our blood vessels, which can lead to heart attacks, stroke, kidney failure and blindness. The reason diabet...
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RESEARCH
What triggers an aneurysm to get bigger, and can we stop it?University of Leeds | Dr Marc Bailey
Abdominal aortic aneurysm (AAA) is a ballooning of the main blood vessel in the body, the aorta. AAAs tend to grow over time and eventually may rupture, which can be fatal. At the moment, the only treatment is surgery if the aneurysm is lar...
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RESEARCH
Unveiling the role of the immune system in hypertrophic cardiomyopathyUniversity of Oxford | Professor Hugh Watkins
Hypertrophic cardiomyopathy, or HCM, is a heart muscle disease that can run in families. It can lead to shortness of breath, chest pain, palpitations, and light headedness and increases the risk of both young and older people dying suddenly...
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RESEARCH
Using stem cells to study atherosclerosis and Marfan syndromeUniversity of Cambridge | Dr Sanjay Sinha
Smooth muscle cells (SMCs) in the blood vessel wall contribute to the ‘furring up’ of vessels in coronary heart disease and stroke. SMCs are also involved in an inherited condition known as Marfan syndrome, where a defect in fibrillin-1, a ...
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RESEARCH
How does blood flow affect new blood vessel formation?University of Sheffield | Professor Tim Chico
Damage to blood vessels can cause serious conditions like coronary heart disease and stroke. Understanding how new blood vessels form, in a process called angiogenesis, and how their growth can be controlled could help scientists devise way...
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RESEARCH
Understanding the communications system of blood vesselsUniversity of Strathclyde | Professor John G McCarron
All blood vessels are lined with endothelium – a layer of cells that control many processes in the circulatory system. Professor McCarron’s work suggests that different endothelial cells have distinct jobs to do and communicate with each ot...
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RESEARCH
Clarifying the link between high blood pressure, its medicines, and type 2 diabetesUniversity of Oxford | Professor Kazem Rahimi
Oxford researchers are using Big Data to understand the links between high blood pressure and diabetes. Millions of people in the UK are living with diabetes and/or high blood pressure, also called hypertension. These conditions raise peop...
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RESEARCH
Plasmacytoid dendritic cell function in the development of atherosclerosisUniversity of Glasgow | Dr Pasquale Maffia
A team led by Dr Pasquale Maffia at the University of Glasgow is interested in the role of immune cells in the circulatory system in the onset of heart and circulatory disease. Much heart disease occurs because of the build-up of fatty, or ...
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RESEARCH
How aldosterone-producing adrenal adenomas cause high blood pressureUniversity of Cambridge | Professor Morris Brown
One cause of high blood pressure is a benign tumour in the adrenal gland which secretes aldosterone, the hormone regulating salt and water balance. The over- secreting tumour is called an aldosterone-producing adrenal adenoma (APA). To unde...