How does blood flow affect new blood vessel formation?

How does blood flow influence Notch signalling?

Tim Chico (lead researcher)

Sheffield, University of

Start date: 27 December 2013 (Duration 2 years 6 months)

Damage to blood vessels can cause serious conditions like coronary heart disease and stroke. Understanding how new blood vessels form, in a process called angiogenesis, and how their growth can be controlled could help scientists devise ways to grow new blood vessels to treat these life-threatening diseases.

Professor Timothy Chico and colleagues have been awarded a three-year grant to find out how angiogenesis is controlled, and how blood flow affects blood vessel growth. The team already knows that a cellular communication pathway, called the Notch signalling pathway, is important for new blood vessel formation, and that blood flow switches off this pathway. Now Professor Chico and his team want to find out how this happens. They will use zebrafish embryos – which have the same signalling pathway – to locate Notch proteins in blood vessel cells. They will then use cutting-edge technologies to measure which proteins are switched on and off by blood flow. This will help scientists devise new therapies to treat diseases caused by damaged blood vessels.

Project details

Grant amount £208,054
Grant type Project Grant
Start Date 27 December 2013
Duration 2 years 6 months
Reference PG/13/2/29902
Status In progress

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