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RESEARCH

Does mutated aquaporin-1 cause pulmonary hypertension?

University of Cambridge | Professor Nicholas Morrell

Pulmonary arterial hypertension (PAH) – high blood pressure in the arteries of the lungs – is a rare but incurable condition that leads to heart failure. Several genetic mutations found in people with PAH patients are known to play an impor...

AI could predict type 2 diabetes up to 10 years in advance

An artificial intelligence (AI) tool that analyses ECG readings during routine heart scans could identify people at risk of type 2 diabetes as much as ten years before they begin to develop the condition, according to research we've funded.

RESEARCH

Studying human kidneys to understand the genes behind high blood pressure

University of Manchester | Professor Maciej Tomaszewski

High blood pressure, or hypertension, is a major and very common risk factor for heart disease. Better ways to identify and treat those at high risk of developing hypertension are urgently needed. Studies of the human genome have uncovered ...

RESEARCH

Investigating the role of SVEP1 in vascular smooth muscle contraction

University of Leicester | Dr Thomas Webb

Leicester researchers will uncover the function of a gene linked to heart disease. Coronary heart disease is the leading cause of death in the UK. Our risk of developing it is determined both by our lifestyle and our genes. Recent resear...

RESEARCH

Studying new-borns to understand the causes of high blood pressure

St George's, University of London | Dr Tarek Antonios

Adults with high blood pressure have a high risk of developing cardiovascular disease, or of having a heart attack or stroke. Understanding the causes of high blood pressure is vital to developing new treatments to prevent these life-threat...

RESEARCH

Studying how aquaporin-1 helps platelets inflate with water in blood clotting

University of Bristol | Professor Alastair Poole

Platelets are important cells in the blood that stick together and help blood to clot when you cut yourself, to stop excessive bleeding when we’re injured. However, they can also do this in the blood vessels of the heart, which can lead to ...

RESEARCH

How platelet numbers and stickiness are controlled in blood clotting

University of Birmingham | Professor Yotis Senis

Professor Yotis Senis is studying platelets, which are the cells that help our blood to clot. Platelets are small cells that plug holes in damaged blood vessels and prevent excessive bleeding. But they can also form clots inside blood ve...

RESEARCH

How can we better identify people with aortic stenosis and cardiac amyloid?

University College London | Professor James Moon

Aortic stenosis (AS) is a common heart valve disease where blood flow through the narrowed aortic valve is restricted. AS increases the risk of death. Transcatheter aortic valve implantation (TAVI) is a common treatment for severe aorti...