Vascular dementia: your questions answered
Professor Philip Bath, Head of Clinical Neuroscience at the University of Nottingham, answers common questions about vascular dementia.
What is the difference between vascular dementia and Alzheimer's disease?
Vascular dementia means that thinking and memory problems are caused by reduced blood supply to the brain, due to blood vessels which are either blocked or have burst.
With Alzheimer's, on the other hand, proteins build up in the brain to form structures called plaques and tangles. This can damage the connections between nerve cells in the brain, and lead to to the death of these cells.
Both types of dementia can affect memory, thinking skills and other mental abilities. Often vascular dementia affects decision-making and thinking first, followed by memory problems, whereas Alzheimer’s typically affects memory first. But in both types, as the condition progresses, it damages all brain functions, so the effects can be similar later on. There is more overlap between types of dementia than we used to think, so we are considering whether potential treatments for one type are relevant for others.
Does stroke cause dementia?
Vascular dementia often follows a stroke (or series of mini-strokes). It can also be caused by white matter disease, a condition involving abnormal function of small blood vessels in the brain. These conditions are all connected. With the help of BHF funding, I am working with experts across the UK to study stroke patients and look at how stroke can lead to dementia. This may help us find out how we could reverse the damage to blood vessels in the brain.
How common is vascular dementia?
An estimated 150,000 people in the UK have vascular dementia, but many others have it in combination with Alzheimer’s.
Does vascular dementia kill you?
Whatever your type of dementia, you will decline with time. A lot of people die of their dementia, not just with it.
Trying to stop stroke leading to vascular dementia
Professor Philip Bath is working on major research, part-funded by the BHF, to find out more about why stroke can lead to dementia:
“With the help of BHF funding, I am working with experts across the UK on a large study of at least 2,000 stroke patients. They will be followed for two years or more to measure their memory and other cognitive skills. This study will allow us to see how we can intervene to help them.
"We know that people with heart attacks and strokes have damaged the lining of the blood vessels and the question is: can this be reversed? Through research with Professor Joanna Wardlaw in Edinburgh, we are trying to modify the way blood vessels decline with age, to maintain blood vessel function.
"It is so important that the BHF is getting involved in this research, because when things go wrong with your circulatory system, they can affect many parts of your body. Most people who have coronary heart disease are likely to have narrowed arteries in other parts of their body, including their brain.
We don’t have a huge number of treatments for dementia, particularly vascular dementia. The explosion in people with diabetes is going to increase it further [as diabetes leads to blood vessel damage]. These conditions are all connected; it is only by tackling them all that we will get successes with new treatments.”
CV – Professor Philip Bath
Stroke Association Professor of Stroke Medicine, University of Nottingham
- Chair and Head of Division of Clinical Neuroscience, University of Nottingham Research interests include treatment of acute stroke and prevention of cognitive impairment following stroke.
- Working on a BHF-funded study to find out how common memory loss and mental decline are after a stroke.