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RESEARCH

A new signalling pathway involved in pulmonary arterial hypertension

University of Leeds | Dr Marc Bailey

Supervised by Professor Chris Peers, a PhD student is investigating a new molecular mechanism involved in the development of pulmonary arterial hypertension (PAH), and testing ways to prevent PAH developing. PAH is a life-threatening dis...

RESEARCH

How the Piezo1 protein helps endothelial cells respond to stretch

University of Leeds | Professor David Beech

Professor David Beech and colleagues at the University of Leeds have been awarded a PhD studentship to allow a young researcher to study the physical forces within blood vessels. They have shown that a protein called Piezo1, an ion chan...

RESEARCH

Visualising the fine structure of heart muscle in 3D using electron tomography

Imperial College London | Dr Pradeep Luther

Hypertrophic cardiomyopathy (HCM) is a heart condition that runs in families and affects the heart’s muscle. In HCM the heart’s muscle becomes thickened and stiff, making it harder for the heart to pump blood around the body. It is a relati...

RESEARCH

New magnetic resonance technology for the University of Oxford

University of Oxford | Professor Damian Tyler

Heart failure is a debilitating condition and can cause breathlessness, making it almost impossible for patients to do even simple exercise such as walking up stairs. During heart failure, changes occur in heart muscle. BHF-funded scient...

RESEARCH

Does the gas carbon monoxide control blood vessel thickening?

University of Leeds | Dr Jonathan D Lippiat

Professor Chris Peers is working out the intricate processes controlling blood vessel thickening to find clues to prevent it happening. In blood vessel disease, the vessel wall often thickens because the muscle cells surrounding vessels...

RESEARCH

A more precise imaging method to diagnose treatable coronary artery disease

University of Oxford | Professor Vanessa Ferreira

Coronary artery disease (CAD) is the narrowing or blockage of blood vessels feeding the heart muscle. Parts of the heart that receive poor blood supply may still be alive, and it is important to identify these parts of the heart because the...

RESEARCH

Can the zebrafish teach us how to repair scarred heart muscle tissue?

University of Bristol | Dr Rebecca Richardson

Unlike us, zebrafish can heal damage to their heart remarkably well. Although heart injury in the zebrafish can result in a scar, this later disappears and it is replaced by new, functional heart tissue. In humans, white blood cells, which ...

RESEARCH

Research excellence at the University of Glasgow

University of Glasgow | Professor Rhian Touyz

The University of Glasgow has received nearly £3 million over the next five years to establish a BHF Centre of Research Excellence in Vascular Science and Medicine led by new BHF professor Rhian Touyz. In 2008, the BHF began a £34 millio...

RESEARCH

Controlling inflammation that arises in atherosclerosis and after a stent

Heriot Watt University, Edinburgh | Professor Stephen Yarwood

Dr Stephen Yarwood is studying ways to combat chronic inflammation, a key part of heart and circulatory disease. In conditions like atherosclerosis, when blood vessels narrow with fatty plaques, chronic inflammation causes excessive leakine...