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  • RESEARCH

    Does a protein called Syk offer hope for new anti-clotting drugs?

    University of Birmingham | Professor Stephen P Watson

    Supervised by BHF Professor Stephen Watson, a PhD student is working to understand if a protein called Syk could help to prevent blood clotting. Platelets are small cells in the blood which clump together at sites of injury to prevent bloo...

  • RESEARCH

    Modelling inflammation in the build-up of arterial plaques

    Imperial College London | Professor James Moore

    Professor James Moore is supervising a PhD student looking at the role of inflammation in atherosclerosis, the build-up of fatty deposits in arteries. Most fatty deposits (called plaques) have inflammation as a hallmark, and all inflammati...

  • RESEARCH

    Studying cells in conditions that resemble the human body

    King's College London | Professor Giovanni Mann

    Endothelial cells that line blood vessels in the human body are exposed to much lower oxygen levels than present in the air we breathe. The percent of oxygen in air is 21% whereas the percent of oxygen in different organs and tissues in the...

  • RESEARCH

    Understanding the role of calcium in platelet activation and clotting

    University of Birmingham | Dr Michael Tomlinson

    Dr Michael Tomlinson from the University of Birmingham is particularly interested in the role of calcium in controlling platelet activity. Although platelets are vital in plugging a site of vessel injury to prevent bleeding, they can also f...

  • RESEARCH

    How do heart muscle fibres respond to their environment?

    Queen Mary, University of London | Dr Thomas Iskratsch

    How do cells know whether they should form heart muscle, a blood vessel or something else? Recent discoveries have shown that one factor influencing heart muscle development is that cells are affected by how rigid their environment is. But ...

  • RESEARCH

    Testing a new ablation method to treat atrial fibrillation

    Imperial College London | Professor Prapa Kanagaratnam

    Dr Prapa Kanagaratnam and his team at Imperial College London are working out if a new ablation protocol to treat atrial fibrillation (AF) can help people avoid the need to attend hospital. AF is the most common type of abnormal heart r...

  • RESEARCH

    Hypertrophic cardiomyopathy: understanding the role of tropomyosin

    University of Kent | Dr Neil Kad

    Hypertrophic cardiomyopathy is an inherited heart muscle disease. If you have the condition, the muscular wall of your heart becomes thickened, making the heart muscle stiff. This thickening makes it harder for your heart to pump blood out ...

  • RESEARCH

    Iron and the heart

    University of Oxford | Professor Samira Lakhal Littleton

    Previous research has shown that manipulating iron levels in the heart could help to treat heart disease. But to manipulate iron in the heart, we first need to understand how iron levels are regulated. Hepcidin is a hormone made in the live...

  • RESEARCH

    Controlling von Willebrand factor as a treatment for stroke

    Imperial College London | Professor David A Lane

    Although stroke patients can be given blood thinning agents to prevent platelets plugging together, they are at risk of the serious side effect of bleeding and also having more strokes in the future. Professor David Lane and colleagues from...

  • RESEARCH

    Von Willebrand factor and it role in blood clotting

    Imperial College London | Professor David A Lane

    Von Willebrand Factor (VWF) is a large blood protein. It helps cells in the blood called platelets recognise blood vessel wall damage, and makes them cluster at the sites of injury. An enzyme called ADAMTS13 controls the activity of VWF. If...