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RESEARCH
Investigating how streptococcus bacteria trigger endocarditisUniversity of Bristol | Dr Angela Nobbs
Endocarditis is an infection that affects the inner lining of the heart. It is a rare but life-threatening condition, usually caused by bacteria that have entered the bloodstream and have circulated to the heart. Oral streptococci bacteria ...
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RESEARCH
Tracing early origins of heart development in the embryo to inform stem cell therapiesUniversity of Oxford | Professor Catherine Porcher
Development of a fully formed heart and circulation in the embryo requires the precise allocation of cells to the right place at the right time. Our understanding of these processes has improved in recent decades but the very earliest stage...
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RESEARCH
Could heart fibroblast cells help to repair damage?Imperial College London | Professor Prakash P Punjabi
Supervised by Prakash Punjabi, a Clinical Research Training Fellow is studying cells within the heart called fibroblasts and how they can support the growth of new heart tissue. Fibroblasts help the body to repair itself after injury. But ...
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RESEARCH
Can blocking the Hippo pathway help keep blood vessels healthy?University of Bristol | Dr Mark Bond
Dr Mark Bond and his colleagues at the University of Bristol are studying how a molecule called cAMP protects blood vessel health to see if manipulating it could treat vascular disease. High levels of cAMP inside the cells that line bloo...
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RESEARCH
Interferon-gamma’s role in development of atherosclerosisCardiff University | Professor Dipak Ramji
Dr Dipak Ramji and Dr Timothy Hughes at Cardiff University are investigating an important molecule in the circulatory system called interferon-gamma, whose action may promote dangerous inflammation of the arteries (a process called atherosc...
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RESEARCH
What are the roles of proteins HD3 alpha and TGF beta in heart fibrosis?King's College London | Dr Lingfang Zeng
Fibrosis is the development of scar tissue, which prevents the heart from working normally and can lead to heart failure. BHF Senior Lecturer Dr Lingfang Zeng and BHF Professor Ajay Shah from King’s College London are interested in the dise...
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RESEARCH
Visualising the fine structure of heart muscle in 3D using electron tomographyImperial College London | Dr Pradeep Luther
Hypertrophic cardiomyopathy (HCM) is a heart condition that runs in families and affects the heart’s muscle. In HCM the heart’s muscle becomes thickened and stiff, making it harder for the heart to pump blood around the body. It is a relati...
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RESEARCH
Can a new drug protect the heart from damage caused by a heart attack?University of Glasgow | Dr William Fuller
Dr William Fuller and colleagues at the University of Dundee are studying new ways to protect heart muscle tissue from injury after a heart attack. When blood vessels become blocked, such as during a heart attack, the amount of oxygen d...
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RESEARCH
Understanding structural changes and altered calcium signalling in the ageing and failing heartUniversity of Manchester | Dr Ashraf Kitmitto
Dr Ashraf Kitmitto and her collaborative team at the University of Manchester are keen to understand why elderly people are prone to heart failure and identify the changes taking place in the heart that lead to disease. Heart failure can oc...