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RESEARCH

Understanding how Popeye protein chemical changes influence heart rate

Imperial College London | Professor Dr Thomas Brand

Professor Thomas Brand from Imperial College London is studying the function of Popeye proteins in the heart and understanding how chemical modifications to these proteins can influence normal heart rhythm. Popeye proteins are located wi...

RESEARCH

How do endothelial cells respond to forces from blood flow at the molecular level?

University of Oxford | Dr Ellie Tzima

Endothelial cells line the inside surface of blood vessels. They are constantly exposed to shear stress – the friction generated by blood flowing across the surface of the cells. Endothelial cells respond to changes in shear stress and t...

RESEARCH

Inhibiting Wnt signalling as a strategy to treat abdominal aortic aneurysm

University of Bristol | Professor Sarah Jane George

An abdominal aortic aneurysm (AAA) is a ballooning of the aorta, the body’s main blood vessel that passes from the heart through the trunk of the body. It’s an extremely dangerous condition; it can develop without symptoms and can burst, ca...

RESEARCH

How Cezanne affects blood vessel narrowing after angioplasty

Queen Mary, University of London | Professor Dr Qingzhong Xiao

Dr Qingzhong Xiao and his team at Queen Mary University of London are studying how a molecule called Cezanne affects restenosis, when arteries re-narrow after coronary angioplasty. Doctors use coronary angioplasty to widen blocked or na...

RESEARCH

Working out how obesity is a risk factor for blood vessel disease

University of Oxford | Professor Charalambos Antoniades

BHF Senior Clinical Research Fellow Professor Charalambos Antoniades is working out why obesity is a risk factor for blood vessel disease, leading to heart attacks and strokes. Fat, or adipose tissue, produces various molecules that hav...

RESEARCH

Do blood vessel stem cells repair damage in atherosclerosis?

King's College London | Professor Qingbo Xu

BHF Professor Qingbo Xu and his team at King’s College London have been studying stem cells that lie in the wall of blood vessels. These cells are thought to be important in repairing damaged blood vessels found in atherosclerosis. Athe...

RESEARCH

Investigating heart condition after repair of Tetralogy of Fallot

King's College London | Jonathan Kentish

Tetralogy of Fallot is a severe heart birth defect that requires corrective surgery. Most patients will die before the age of 20 without the surgery, but the best age at which to have the procedure is not known. The surgery can cause a hear...