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RESEARCH
How does a molecule called ATP prevent dangerous calcium build up in blood vessels?Royal Veterinary College, University of London | Dr Isabel Orriss
Dr Isabel Orriss is studying a process called calcification, when bone-like deposits of a mineral called calcium phosphate build up in the arteries, heart valves and heart muscle tissue. Calcification often occurs in people with diabet...
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RESEARCH
Using nanomaterials to lower cholesterolUniversity of Surrey | Dr Daniel Whelligan
Atherosclerosis, where blood vessels become ‘furred up’ and narrowed, is a major cause of death and disability in the UK. Statins are used to lower cholesterol for those with, atherosclerosis but they are not always well tolerated. There ar...
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RESEARCH
Explaining why some nanoparticles are harmfulUniversity of Edinburgh | Dr Mark Miller
Dr Mark Miller is working out whether a group of fats made in the body are responsible for harming our heart and circulatory system. The fats, called eicosanoids, may be causing the harmful effects that very small particles, known as nanopa...
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RESEARCH
Understanding genetic errors that affect myosin in cardiomyopathyUniversity of Kent | Professor Michael Geeves
Individuals with inherited genetic errors in heart muscle proteins are at risk of sudden death at any age. This is because the error leads to two major types of heart disease: a thickened heart wall (called hypertrophic cardiomyopathy); or ...
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RESEARCH
The highs and lows of stress in the heartUniversity of Reading | Professor Angela Clerk
Heart muscle cells work hard to pump blood through the body and are subjected to a number of stresses, including oxidative stresses, where high levels of molecules called reactive oxygen species can cause death of heart muscle cells. This c...
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RESEARCH
Alternative ways to treat pulmonary hypertensionImperial College London | Professor Ian Adcock
Pulmonary arterial hypertension (PAH) is abnormally high blood pressure in the arteries carrying blood to the lungs, causing damage to the right side of the heart. Symptoms include breathlessness or tiredness. The condition can lead to deat...
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RESEARCH
Re-purposing old medicines as a new way to prevent sudden cardiac deathSt George's, University of London | Dr Angeliki Asimaki
Arrhythmogenic cardiomyopathy (ACM), also known as ARVC, is a heart disorder that runs in families and can cause sudden disruptions to the heart’s rhythm and death – even in seemingly healthy young people. There is an urgent need for medici...