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RESEARCH
Are chemical modifications of DNA involved in atherosclerosis?University of Bristol | Professor Andrew Newby
BHF Professor Andrew Newby has been awarded a three year grant to investigate the intricate processes that lead to plaque rupture in atherosclerosis. Atherosclerosis occurs when fatty deposits build up inside artery walls and harden, causin...
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RESEARCH
Do tiny packages produced by platelets cause inflammation in atherosclerosis?University of Birmingham | Professor Ed Rainger
Platelets, cells that cause blood clotting, secrete tiny packages into the blood, filled with protein and other molecules. Professor Ed Rainger, at the University of Birmingham, will find out if these tiny packages can promote inflammation ...
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RESEARCH
Understanding the early stages of how our veins and arteries stiffen with ageUniversity of East Anglia | Dr Derek Warren
As we age, our veins and arteries become less flexible, and this contributes to the development of heart and circulatory disease. The biological processes that initiate the stiffening of our blood vessels are still not well understood. By u...
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RESEARCH
Tracking down the DNA regions that are important to blood clottingUniversity of Exeter | Dr Mattia Frontini
Heart attacks and most strokes occur when a blood clot forms in one or more of the arteries feeding the heart or brain, respectively. Thanks to the tireless efforts of researchers, we now have a better understanding of the processes in the ...
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RESEARCH
Deciphering the intricate process controlling plateletsUniversity of Birmingham | Dr Alexandra Mazharian
BHF Intermediate Basic Science Research Fellow Dr Alexandra Mazharian is working out the intricate processes behind production of platelets - small fragments of bone marrow cells called megakaryocytes (MK cells) that circulate in the blood ...
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RESEARCH
How variations in our DNA affect blood vessel smooth muscle cellsUniversity of Leicester | Professor Shu S Ye
Advances in technology have generated an avalanche of data about the genetics of health and disease. Leicester has been at the forefront of finding variations in a person’s genetic code that are linked to an increased risk of heart disease....
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RESEARCH
Finding a weakness in how bacteria grow on medical devices, to prevent infectionUniversity of York | Dr Michael Plevin
Advances in research and technology have led to the development of a wide range of medical devices used to treat heart disease. Devices like pacemakers, prosthetic heart valves and stents may be placed inside patients’ bodies for year...
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RESEARCH
Studying the role of cilia in blood vessel growthUniversity of Leeds | Dr Georgia Mavria
After a heart attack or stroke, it’s essential that new blood vessels form to re-establish blood flow and keep surrounding tissue alive. A key step in making blood vessels that function properly is the development of the vessel lumen – the...
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RESEARCH
Which immune cells cause blood vessel inflammation in atherosclerosis?University of Cambridge | Professor Ziad Mallat
BHF Professor Ziad Mallat is studying how blood vessels become inflamed in atherosclerosis to see if there is a way of preventing inflammation. Atherosclerosis is caused by the build-up of fatty plaques in the walls of our arteries, and ...