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Scientists we fund have made a breakthrough in understanding the process that leads to a blood clot forming in the lungs - a condition that kills more than two thousand people in the UK each year.

The ‘fat but fit’ paradox – where some people who are overweight have a seemingly healthy metabolism – may be explained by a good blood supply to their fat cells, according to new research we funded. The findings suggest that encouraging the growth of new blood vessels in fat could offer some protection against heart attacks and strokes.

New research we funded un Dundee suggests that e-cigarettes or vaping may be less harmful to blood vessels than smoking.

RESEARCH

Queen Mary, University of London | Dr Mathieu Benoit Voisin

During a heart attack or stroke, blood supply to a part of the heart or brain is cut off, causing tissue damage. Reperfusion injury is the additional tissue damage that occurs once the blood supply is restored. Reperfusion injury is also a ...

RESEARCH

University of Leicester | Dr Matthew Graham-Brown

This Leicester team is testing whether slowing down kidney dialysis reduces damage to patients’ hearts. Heart disease is the leading cause of death for people with kidney failure on dialysis. To stay alive, patients on dialysis have thei...

RESEARCH

University of Bristol | Dr Emma Hart

The number of young adults (aged 18-40 years) with high blood pressure, known as hypertension, is rising. This is worrying because high blood pressure is a leading cause of heart and circulatory disease. It is not clear why young people g...

RESEARCH

University of Reading | Professor Angela Clerk

Several drugs to treat cancer are known to have long-term side effects on the heart. Among them are drugs that impact a series of proteins which talk to each other, called the ERK1/2 pathway. This pathway promotes cancer, but it also protec...

RESEARCH

Queen Mary, University of London | Professor Philip Eaton

The build-up of scar tissue in the heart in response to injury such as a heart attack - a process called fibrosis - is a contributing factor to heart failure. During this process, some heart muscle cells change their identity and become fi...

RESEARCH

University of Leicester | Professor David G Lambert

Although sepsis begins with infection, it can very quickly escalate to a severe immune reaction and circulatory problems. Blood pressure falls, and vital organs shut down because they do not receive the blood they need. Professor Lambert ...

RESEARCH

University of Bristol | Dr Danielle Paul

For our hearts to beat and pump blood around the body, heart muscle needs to contract. Under the microscope, we can see that heart muscle is made up of two sets of filaments – thin and thick – which are made from several different proteins....