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There are 3429 result(s) for coronary disease mortality
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RESEARCH
Getting FISSical to understand heart muscle contractionKing's College London | Dr Yin Biao Sun
Each heart beat is triggered by a pulse of calcium in a heart muscle cell, and is driven at the molecular level by myosin and actin filaments sliding past each other and generating the force for contraction. Calcium triggers contraction by ...
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RESEARCH
Investigating fibroblast growth signals to stop hypertrophy in the heartUniversity of Manchester | Dr Delvac Oceandy
Heart failure is a life-threatening condition that develops when the heart becomes damaged because of a heart attack, high blood pressure or an inherited heart condition. In most cases, the heart fails because heart muscle cells overgrow - ...
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RESEARCH
Uromodulin – a good target for high blood pressure?University of Glasgow | Professor Sandosh Padmanabhan
In the UK, around a third of all adults have high blood pressure, putting them at higher risk of heart and circulatory disease, and people with kidney problems often develop high blood pressure and heart disease such as heart failure, strok...
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RESEARCH
Developing smarter heart valves that last longerUniversity of Bristol | Professor Gianni D Angelini
BHF Professor Gianni Angelini is looking for ways to prolong the life of biological prosthetic heart valves used to replace faulty valves in people with heart valve disease. Many people with heart valve disease need little or no treatme...
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RESEARCH
Which immune cells cause blood vessel inflammation in atherosclerosis?University of Cambridge | Professor Ziad Mallat
BHF Professor Ziad Mallat is studying how blood vessels become inflamed in atherosclerosis to see if there is a way of preventing inflammation. Atherosclerosis is caused by the build-up of fatty plaques in the walls of our arteries, and ...
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RESEARCH
Understanding how different heart cells work togetherImperial College London | Professor Cesare M N Terracciano
Professor Cesare Terracciano's team is working out how different cells within the heart interact with each other and how these relationships affect the way the heart pumps. The heart muscle is made up of cells called cardiomyocytes, which...
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RESEARCH
Studying BMP9, a potential therapy for pulmonary arterial hypertensionUniversity of Cambridge | Dr Wei Li
Pulmonary arterial hypertension (PAH) is a rare but devastating condition, for which effective treatments are urgently needed. In PAH, the blood pressure in the arteries supplying the lungs is very high. This puts a strain on the right side...
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RESEARCH
Understanding how Ang2 switches from being helpful to harmful in blood vesselsUniversity of Leicester | Professor Nicholas Brindle
People who have had heart attacks, heart failure or need a heart transplant have high levels of a protein called Ang2 in their blood. In these people, there is a switch in their blood vessels that makes them respond differently to Ang2. Thi...
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RESEARCH
Does cholesterol alert our immune system to atherosclerosis?University of Cambridge | Dr Meritxell Nus Chimeno
Atherosclerosis is the build-up of fatty material inside your arteries, causing them to harden and narrow, which can eventually trigger a heart attack or stroke. B cells are a type of immune cell whose role is to produce antibodies to help...
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RESEARCH
Pre-eclampsia – effect of certain growth factors on the mother’s blood vesselsUniversity of Nottingham | Professor David Bates
Pre-eclampsia in pregnancy, is one of the main causes of illness or death in pregnant women. Complications such as high blood pressure, swelling and the presence of protein in urine can commonly lead to life-threatening conditions such as l...