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  • RESEARCH

    How intensively should we treat blood pressure in people with disease of the small blood vessels in the brain?

    University of Cambridge | Professor Hugh Markus

    Disease of the small blood vessels in the brain is an important cause of stroke and is the most common cause of cognitive impairment and dementia. High blood pressure is the major factor causing small vessel disease of the brain. We know t...

  • RESEARCH

    Harnessing the body’s natural defences against blood vessel damage

    University of Sheffield | Dr Alfred Thompson

    Pulmonary arterial hypertension (PAH) is a devastating condition caused when the blood vessels in the lung become progressively narrower. This causes increased blood pressure in the lungs and can lead to heart failure. This abnormal narrow...

  • RESEARCH

    How does COPD increase the risk of heart failure?

    University of Manchester | Dr Christopher Miller

    Chronic obstructive pulmonary disease (COPD) is the name for a group of conditions that cause severe breathing difficulties. A third of people with COPD also have heart failure. You might expect this to be because the two diseases share ris...

  • Video: What to pack for a hospital stay

    Learn what to pack for hospital with our exclusive video and list of 12 things to pack, specially written for those who are having a heart operation.

  • First-of-its-kind trial testing diabetes drug to treat deadly aneurysms

    A Leicestershire farmer has become the first person in the UK to join a trial, funded by us, to test whether the type 2 diabetes drug metformin can treat deadly abdominal aortic aneurysms

  • RESEARCH

    Which proteins determine the correct function of artery cells?

    University of Cambridge | Professor Christopher W J Smith

    Professor Christopher Smith and his colleagues at the University of Cambridge are studying a group of proteins that help to determine the correct function of vascular smooth muscle cells (VSMC) that line arteries. DNA is a chemical code th...

  • RESEARCH

    Identifying critical mechanisms in the initiation of atherosclerosis

    Imperial College London | Professor Peter Weinberg

    Atherosclerosis develops when fatty deposits build up in the walls of arteries narrowing them and thus reducing the amount of blood reaching organs. If a fatty plaque ruptures it can block the artery and cause a heart attack or stroke. We k...

  • RESEARCH

    Could blocking a protein called EPAC1 prevent heart and circulatory disease?

    Heriot Watt University, Edinburgh | Professor Stephen Yarwood

    Dr Stephen Yarwood from Heriot Watt University in Edinburgh is working out if blocking an enzyme called EPAC1 could treat heart and circulatory diseases associated with metabolic syndrome – a combination of diabetes, high blood pressure and...

  • RESEARCH

    Understanding how NPP1 works to prevent artery calcification

    University of Edinburgh | Dr Vicky MacRae

    Heart and circulatory diseases are common complications of people with kidney disease. This is mainly due to a build-up of bone-like deposits in their arteries – causing them to stiffen and narrow. This is called calcification and can lead...

  • RESEARCH

    Blocking inflammation in arteries to prevent heart disease

    University of Strathclyde | Professor Robin Plevin

    CXCL12 is a molecule that causes inflammation and has been linked to the development of heart and circulatory diseases. Researchers are now interested in whether they can stop it working in blood vessel cells and whether this might help pre...