Waste and fluid accumulation in vascular dementia

Vascular dementia: failure of fluid drainage from cerebral white matter (Joint funding with Stroke Association and Alzheimer's Society for Advancing Care and Treatment of Vascular Dementia (ACT-VAD))

Roxana Carare (lead researcher)

Southampton, University of

Start date: 01 September 2017 (Duration 3 years)

Dr Roxana Carare from the University of Southampton is studying vascular dementia, a common form of dementia where the brain’s blood supply is impaired. She believes vascular dementia happens because the brain cannot get rid of waste and fluid properly. The brain removes its waste along extremely thin pathways embedded in the walls of narrow blood vessels. Dr Carare believes vascular dementia occurs in part because these pathways are not correctly anchored to the blood vessel wall. This means that water channels do not work correctly and waste cannot be eliminated properly from the brain. In this project, jointly funded by the BHF, the Stroke Association and Alzheimer’s Society, Dr Carare will study how this ‘anchoring’ affects water transport and the brain. She will study waste elimination in mice with disrupted anchoring, and compare these mouse brains with human brains with vascular dementia. She will also analyse mouse brains with disrupted channels for water exchange. This research could lead to targeted treatments for vascular dementia that work by draining waste fluid from the brain.

Project details

Grant amount £97,120
Grant type Special Project
Start Date 01 September 2017
Duration 3 years
Reference SP/17/6/33092
Status In progress

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