How are LXRs and IRF8 involved in the development of atherosclerosis?

Understanding the role of interferon regulatory factor 8 on the anti-atherogenic actions of LXR

This study will investigate the relationship between Liver X receptors (LXRs) and another key protein, called IRF8, which plays a critical role in the development of new immune cells during inflammation. LXRs are cholesterol ‘sensors’ in the body and help regulate inflammation, which contributes to atherosclerosis – the furring-up of the walls in major blood vessels. It is the underlying cause of most heart attacks and strokes. Understanding how these proteins function will help scientists develop new medicines that will tackle this harmful condition. Dr Ines Pineda Torra and Professor Ian Zachary have been awarded a three-year grant to work out how LXRs affect the development of atherosclerosis. In mice, researchers have shown that LXRs can help prevent and even reverse atherosclerosis. The information gained from this research will help them identify potential new targets for medicines that could prevent and control atherosclerosis.