The second extracellular loop of the CGRP receptor: A docking site for vasoprotective ligands
New treatments are urgently needed to combat heart disease, one of the biggest killers in the UK. Understanding the molecular basis for the normal function of the heart and circulatory system is central to being able to develop new ways to correct the errors that may arise. A research team led by Dr Alex Conner at the University of Warwick is investigating the structure and function of a receptor in the heart and circulatory system for a small protein called CGRP, which has a protective effect on the heart and the blood vessels. Using sophisticated computer modelling and experiments in cells, they will look at how the binding occurs. They are particularly interested in defining the characteristics of a particular area on the receptor called the ‘extracellular loop’ which is thought to be vital for its effective function. The results will be important for building on future research that is aiming to develop new medicines for cardiovascular disease that mimic the action of the CGRP receptor.
Project details
| Grant amount | £191,218 |
|---|---|
| Grant type | Project Grants |
| Application type | Project Grant |
| Start Date | 01 January 2014 |
| Duration | 3 years |
| Reference | PG/12/59/29795 |
| Status | Complete |
