Interferon-gamma’s role in development of atherosclerosis

The role of the extracellular signal-regulated kinase/signal transducer and activator of transcription 1 axis in atherosclerosis

Dr Dipak Ramji and Dr Timothy Hughes at Cardiff University are investigating an important molecule in the circulatory system called interferon-gamma, whose action may promote dangerous inflammation of the arteries (a process called atherosclerosis). Over time, fatty material and trapped immune cells build up in the vessel wall, forming a plaque. Some plaques become unstable and can rupture, triggering a blood clot. If the clot blocks blood flow to the heart, a heart attack may occur. The researchers are looking at a sequence of molecular events involving interferon-gamma to understand more about the disease process in mice. It is thought that interferon-gamma may stimulate the production of proteins which increase the build-up of fatty plaque. One protein that is required for the action of interferon-gamma is called STAT1. Understanding the relationship between interferon-gamma and STAT1 may help identify ways to prevent dangerous atherosclerosis.