The role of TGFß signalling in angiogenic and haemogenic endothelial cell programming
Formation of the vascular network that carries blood, oxygen and nutrients around the body begins early in the embryo. The main vessels - arteries and veins - are formed first and soon after smaller vessels develop from the main vessels to form the vasculature. At the same time blood stem cells arise from cells of the main artery; these will in turn give rise to all the blood and immune cells we will need throughout our adult lives. What makes a cell become part of a vessel or give rise to a blood stem cell is still unclear, but often extracellular growth factors are involved. In this Intermediate Basic Science Fellowship, Dr Rui Monteiro from the University of Oxford will investigate how a growth factor called transforming growth factor ? (TGF?) regulates both blood cell and blood vessel formation. Understanding how the development of blood and vessels are regulated will help devise therapies that could help grow new blood vessels or blood cells for cardiovascular disease.
Project details
| Grant amount | £927,023 |
|---|---|
| Grant type | Fellowships |
| Application type | Intermediate Basic Science Research Fellowship |
| Start Date | 01 January 2014 |
| Duration | 6 years, 10 months |
| Reference | FS/13/50/30436 |
| Status | In Progress |
