Do mast cells worsen deep vein thrombosis?

The role of mast cells in deep vein thrombosis

Alexander Brill (lead researcher)

Birmingham, University of

Start date: 01 March 2014 (Duration 3 years)

Mast cells form an important part of our immune system, but may worsen or play a part in the onset of deep-vein thrombosis (DVT*). In DVT, mast cells appear to cause the blood vessel lining endothelial cells to encourage the formation of clots. Dr Alexander Brill from the University of Birmingham has been awarded a 3-year grant totalling £223,000 to look into the role of mast cells in DVT. Dr Brill’s previous research has shown that mice lacking mast cells had complete protection from DVT and less clot-forming activity by the endothelial cells. He is looking to build on this important early work, characterising further the role of mast cells in the development of DVT in mice.

*DVT – where blood clots block blood flow in veins – can be catastrophic and life-threatening. Current ways to prevent or treat DVT can have unwanted side effects such as bleeding and so a complication-free approach is needed. Medicines that target the mast cells in patients with DVT could one day offer an effective and safe approach to tackling these blood clots.

Project details

Grant amount £223,024
Grant type Project Grant
Start Date 01 March 2014
Duration 3 years
Reference PG/13/60/30406
Status Complete

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