The role of FXIII/Fibrinogen αC interactions in clot stabilisation and fibrinolysis
Although blood clotting is an important response to injury, under certain circumstances a blood clot called a thrombus can grow in a blood vessel, blocking the flow of blood and even breaking free from the vessel wall. A thrombus in the circulatory system can be very dangerous – it can cause thrombosis, where it blocks blood flow to tissues. In the brain, this can cause a stroke, and in the heart it’s the final stage in the sequence of events leading to a heart attack. Professor Peter Grant and his team from the University of Leeds are investigating the role of two proteins called factor XIII and fibrinogen, which help the parts of a blood clot stick together. Their work will help us understand more about how clot components interact and lead to formation or breakdown and may help to develop new treatments to tackle dangerous clotting in blood vessels.
Project details
| Grant amount | £183,218 |
|---|---|
| Grant type | Project Grants |
| Application type | Project Grant |
| Start Date | 01 April 2012 |
| Duration | 3 years |
| Reference | PG/11/96/29174 |
| Status | Complete |
