The role of extracellular matrix laminin-10 in vascular inflammation, blood-brain barrier repair and angiogenesis after cerebrovascular disease (Miss Hannah Thurgur)
Dr Emmanuel Pinteaux from the University of Manchester is searching for ways to prevent inflammation in the brain’s blood vessels during a stroke. Whilst inflammation is an important defence against injury or infection, in the brain it can be very damaging after stroke. A faulty blood-brain barrier (a group of cells that separates the circulating blood from the brain and protects the brain from infection and toxins) also contributes to brain damage. Treatments that target inflammation and repair the blood brain barrier could improve people’s recovery chances. Dr Pinteaux has found that a molecule called interleukin-1 (IL-1) is released during a stroke, causing blood vessel inflammation and damaging the blood brain barrier. IL-1 also triggers blood vessel cells to produce laminin-10, a molecule essential for repairing brain blood vessels and the barrier. In this project, Dr Pinteaux’s PhD student will work out whether laminin-10 could treat people who have had a stroke. The student will find out if it regulates inflammation in the brain in mice, repairs the blood brain barrier, grows new blood vessels and makes cells work properly after stroke. This research will reveal if laminin-10 is a new way to recover normal brain function after a stroke, or to treat other conditions such as heart disease.
Project details
| Grant amount | £120,799 |
|---|---|
| Grant type | Fellowships |
| Application type | PhD Studentship |
| Start Date | 01 April 2017 |
| Duration | 3 years |
| Reference | FS/17/6/32616 |
| Status | In Progress |
