The role of adiponectin in the regulation of vascular and myocardial superoxide generation in human coronary artery disease
Adipose tissue is not just an inert collection of fat cells found on our legs and stomach. Adipose tissue also surrounds our blood vessels and it’s now known that it secretes proteins, called adipokines, which have biological effects. One of these adipokines, adiponectin, counteracts inflammation, although how exactly it works in people is not known. Dr Charalambos Antoniades and his team will investigate this further in this fellowship. He will study adipose tissue, blood vessel samples and small samples of heart muscle taken from patients undergoing coronary artery bypass surgery (CABG) who’ve volunteered for the study. Dr Antoniades will examine how adiponectin affects the biology of blood vessels and heart cells, and whether it is involved in the risk of postoperative complications after CABG, for example postoperative heart rhythm disturbances.
Project details
| Grant amount | £906,121 |
|---|---|
| Grant type | Fellowships |
| Application type | Intermediate Clinical Research Fellowship |
| Start Date | 01 June 2011 |
| Duration | 4 years |
| Reference | FS/11/66/28855 |
| Status | Complete |
