The effects of modulating circulating Factor XIII-A concentration upon thrombus volume
Blood clots inside arteries can prevent blood from flowing and so cause illness and death. This is what happens inside the coronary artery to cause a heart attack. A blood clotting protein called FXIII-A strengthens blood clots and may worsen the blockage to blood flow. In this project, based at the University of Leeds, the student will use modern genetic techniques to reduce the amount of FXIII-A in mice to see if this lessens the amount of clot that develops inside blood vessels. If they find that reducing FXIII-A levels reduces the size of blood clots, then this may mean that developing drugs that interfere with the activity of FXIII-A could treat human diseases including heart disease.
Project details
| Grant amount | £114,413 |
|---|---|
| Grant type | Fellowships |
| Application type | PhD Studentship |
| Start Date | 01 August 2013 |
| Duration | 3 years |
| Reference | FS/13/36/30243 |
| Status | Complete |
