Investigating the potential to control blood vessel growth in disease

The angiogenic potential of regulation of VEGF mRNA 3'processing

Throughout our life, new blood vessels grow to maintain a healthy circulatory system – a process called angiogenesis. However, the formation of new blood vessels can also occur in conditions such as heart disease and diabetes and can lead to problems. Professor David Bates and his team from the University of Nottingham are investigating the factors that control blood vessel growth. In particular they are looking at a molecule called vascular endothelial growth factor (VEGF). Past research has shown that there are two subtypes of VEGF – one that prevents vessel growth and one that promotes it. The Nottingham team will identify the factors that control the balance of these subtypes. Their findings may lead to new treatments that work adjusting the levels of each.