Studying novel modes of autophagy regulation and their roles in heart failure
Over half a million people in the UK have been diagnosed with heart failure, when the heart lacks the strength to pump blood around the body efficiently. The condition gets worse over time, and can be severely debilitating and distressing. Researchers around the world are urgently searching for ways to prevent, treat and cure heart failure. Autophagy is an important maintenance system inside our cells, working to dismantle and dispose of old or redundant cell parts and provides a source of fuel. This system is faulty in heart disease, where heart muscle cells work less effectively. This can contribute to the development of heart failure. In this project, BHF Intermediate Fellow Dr Burgoyne will delve into the control processes that govern autophagy, aiming to reveal how and why the system goes wrong in heart disease. Understanding the fine details of autophagy control will lay the foundations for future heart failure research. Ultimately, targeting autophagy could be a new avenue to explore in the global endeavour to prevent or treat heart failure, which is a growing health issue.
Project details
| Grant amount | £236,941 |
|---|---|
| Grant type | Project Grants |
| Application type | Project Grant |
| Start Date | 21 March 2018 |
| Duration | 3 years |
| Reference | PG/17/14/32867 |
| Status | In Progress |
