Role of R-SPONDIN3 signalling in the determination of obesity phenotypes/fat distribution and susceptibility to cardiovascular disease
Obesity is a major risk factor for the development of cardiovascular disease. People who are overweight due to fat deposition around the abdomen (so-called ‘apple-shaped’ individuals) seem to have a higher risk of heart disease than those who tend to deposit fat in the buttocks and thighs (‘pear-shaped’ people). This Oxford research team, led by Professor Fredrik Karpe and Dr Constantinos Christodoulides, aims to identify some of the factors controlling the size and function of these different areas of fat. The researchers are focusing on a particular gene called R-SPONDIN3, which is thought to play a part in controlling fat distribution. They hope to understand more about the expression and activity of this gene in different areas of the body, and also its effect on individual fat cells, through laboratory experiments. The ultimate aim of their research is to confirm that R-SPONDIN3 should be studied further as a treatment target to manipulate the way fat is stored in the body, in order to help lower cardiovascular risk.
Project details
| Grant amount | £266,690 |
|---|---|
| Grant type | Project Grants |
| Application type | Project Grant |
| Start Date | 10 July 2013 |
| Duration | 3 years |
| Reference | PG/12/78/29862 |
| Status | Complete |
