Role of neuropilin 1 in controlling endothelial cell signalling and migration in response to extracellular matrix components
Finding out how new blood vessels grow is important for developing treatments to restore blood flow in tissues that are starved of oxygen (ischaemic tissue). Neuropilin-1 (NRP1) is a protein in the endothelial cells that line the inside of blood vessels. There it serves as a receptor for the vascular growth factor VEGF, which binds to NRP1 and promotes blood vessel growth. NRP1 also interacts with scaffold proteins that surround the endothelial cells. In this fellowship Dr Raimondi, who is based at the University College London Institute of Ophthalmology, will find out more about the different NRP1 interactions to understand how NRP1 promotes blood vessel growth in tissues that are starved of oxygen.
Project details
| Grant amount | £185,945 |
|---|---|
| Grant type | Fellowships |
| Application type | Immediate Postdoctoral Basic Science Research Fellowship |
| Start Date | 07 June 2013 |
| Duration | 3 years |
| Reference | FS/13/35/30148 |
| Status | Complete |
