Role of Bcar1/p130Cas in heart development
Each day in the UK, 12 babies are diagnosed with congenital heart defects, which are abnormalities in the structure of the heart or its blood vessels. Congenital defects occur when the heart fails to develop normally in the embryo . Many molecules play important roles in the normal development of the heart and blood vessels. Professor Ian Zachary and his team have discovered that a molecule called Bcar1 is one of them. When they switched off Bcar1, in embryos from mice, a variety of heart abnormalities developed, including a defect called truncus arteriosus. This is a feature of several human congenital heart conditions, which suggests that Bcar1 might be important in causing heart defects in babies. In this study, the team will find out more about how Bcar1 controls heart development. They will identify which type of cell Bcar1 is acting on and the mechanisms involved. Understanding more about how the normal heart develops will help understand better how congenital defects occur.
Project details
| Grant amount | £265,945 |
|---|---|
| Grant type | Project Grants |
| Application type | Project Grant |
| Start Date | 01 May 2017 |
| Duration | 3 years |
| Reference | PG/17/20/32864 |
| Status | In Progress |
