Regulation of the PP2AC, PP4C, PP6C and alpha4 signalling axis in the myocardium: roles in calcium homeostasis and myocyte hypertrophy
In this studentship, the researchers will study the function of a family of enzymes, the protein phosphatases (PP2A, PP4 and PP6) and their regulatory protein, alpha 4, in heart cells. They believe that these enzymes are involved in controlling the flow of calcium inside the heart, which is needed for the heart to beat properly, and in controlling heart cell overgrowth (hypertrophy), which can lead to heart failure. Human heart failure is associated with increased PP2A expression and activity, which suggests that these proteins are important in cardiovascular disease. Understanding how calcium inside the heart cell and hypertrophy of heart cells is controlled could be useful for the development of new treatments for heart failure.
Project details
| Grant amount | £109,241 |
|---|---|
| Grant type | Fellowships |
| Application type | PhD Studentship |
| Start Date | 28 January 2013 |
| Duration | 3 years |
| Reference | FS/12/45/29647 |
| Status | Complete |
