Regulation of the Germinal Centre Kinase (GCK) MST3 by STRiatin-Interacting Phosphatase And Kinase (STRIPAK) complexes
Professor Angela Clerk is studying how certain signals that help the heart respond to stress are regulated in the heart. When the heart goes through a stressful event, such as high blood pressure or a heart attack, heart muscle cells die and the heart cannot function properly. Initially, surviving cells increase their ability to contract and other cells repair the damage, but eventually the continued stress may lead to heart failure. In this project, Professor Clerk will investigate a complex of proteins called striatin and MST3 in rats and mice. The heart contains large amounts of these proteins, suggesting they help it to respond to stress and help maintain or control heart function in health and disease. If MST3 is released from this complex, it starts off signals that contribute to changes associated with heart failure. Research also suggests they these proteins have a role in high blood pressure, arrhythmias and cardiomyopathy. Professor Clerk will use a range of approaches to understand how striatin and MST3 form a complex and how they function in the heart. This research will establish if striatin and MST3 or their control mechanisms could be manipulated using drugs to prevent or treat heart failure.
Project details
| Grant amount | £153,866 |
|---|---|
| Grant type | Project Grants |
| Application type | Project Grant |
| Start Date | 01 January 2016 |
| Duration | 1 year, 6 months |
| Reference | PG/15/41/31560 |
| Status | Complete |
