Regulation of platelet activation and thrombosis by the G6b-B-Shp1/2 signalling complex
Platelets are small blood cells that plug holes in damaged blood vessels. They do this by sticking to sites of vessel injury and forming a clot that plugs the damaged blood vessel. Platelets can also have a detrimental effect on health by forming a clot inside diseased blood vessels that supply blood to the heart and brain, leading to heart attacks and strokes. In this Senior Basic Science Research Fellowship, Professor Senis will investigate how a protein found on the surface of platelets, called G6b-B, controls the number of platelets in the blood and how sticky they are. He will also investigate how G6b-B sends biochemical signals inside platelets by activating two related signalling proteins called Shp1 and Shp2, that control platelet production and stickiness.
Project details
| Grant amount | £906,846 |
|---|---|
| Grant type | Fellowships |
| Application type | Senior Basic Science Research Fellowship |
| Start Date | 01 January 2013 |
| Duration | 5 years |
| Reference | FS/13/1/29894 |
| Status | Complete |
