Regulation of cardiomyocyte cell cycling by nuclear NOX4D
BHF Professor Ajay Shah and his team at King’s College London want to find out if a protein called Nox4D could help the heart recover after a heart attack by making healthy heart muscle cells divide. Scientists have recently found that heart muscle cells can divide to form new heart cells after a heart attack, particularly if they are next to an area of injury. Enhancing this might be a new way to repair heart damage. Professor Shah has discovered that a protein called Nox4D makes heart muscle cells divide in the lab. He also found that mice with higher Nox4D levels in their heart have more heart muscle cells. In this project, he will find out if Nox4D boosts heart muscle cell division in adult mice, and if increasing levels of Nox4D could improve recovery and make the heart work better after a heart attack. By working out how heart muscle cells divide to make new cells, this research could lead to new medicines that help to repair the heart after a heart attack.
Project details
| Grant amount | £300,162 |
|---|---|
| Grant type | Project Grants |
| Application type | Project Grant |
| Start Date | 10 October 2016 |
| Duration | 3 years |
| Reference | PG/16/70/32310 |
| Status | Complete |
