How does carbon monoxide affect the normal heart beat?

Regulation of cardiac ERG K+ channels by carbon monoxide

Chris Peers (lead researcher)

Leeds, University of

Start date: 06 January 2014 (Duration 3 years)

Carbon monoxide inhalation is the most common form of death by poisoning and can cause dangerous disruption to heart rhythm. Professor Chris Peers and co-workers based at the University of Leeds are carrying out BHF-funded research into the effects of carbon monoxide poisoning on the heart. Usually, our heartbeat is a coordinated electrical impulse that spreads through the heart. However, carbon monoxide poisoning commonly disrupts this electrical wave, leading to heart-rhythm abnormalities. The research group will focus on the effect of carbon monoxide molecules on sodium and potassium in the heart. These chemicals help to control the coordinated electrical impulse involved in each heartbeat. Understanding more about how carbon monoxide causes such damage to the heart is necessary to developing treatment for poisoned individuals.

Project details

Grant amount £203,837
Grant type Project Grant
Start Date 06 January 2014
Duration 3 years
Reference PG/13/61/30410
Status Complete

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