Copying a natural repair system to develop new drugs for heart disease

Quantitative evaluation of the cardiovascular effects of two allosteric enhancers of the adenosine A1-receptor that differentially alter efficacy and affinity

Jeanette Woolard (lead researcher)

Nottingham,University of

Start date: 01 July 2015 (Duration 3 years)

A molecule called adenosine is released from cells throughout the body to help protect them and repair them when damaged. Scientists hope to develop drugs that mimic how adenosine works to produce similar protective and healing effects.

The BHF has awarded a grant to Dr Jeanette Woolard at the University of Nottingham to look at how drugs that target the adenosine receptors in the heart and circulatory system could prevent and repair disease. This research will establish which combinations of molecules produce the most selective and effective responses in the heart and circulatory system, and will reveal how they work. It could open up avenues to discover develop new drugs that treat heart and circulatory diseases with fewer side effects.

Project details

Grant amount £239,829
Grant type Project Grant
Start Date 01 July 2015
Duration 3 years
Reference PG/14/95/31248
Status In progress

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