Prevalence and determinants of subclinical cardiovascular dysfunction in adults with Type 2 Diabetes Mellitus (Dr Gaurav Gulsin)
Supervised by Professor Gerald McCann, the Clinical Research Training Fellow on this grant is working out why heart failure develops in people with diabetes and if there are ways to detect it early. Heart failure is one of the main causes of poor health and premature death in people with diabetes. We don’t know exactly how many people with diabetes develop heart failure, why they are particularly at risk of developing it, and how to detect deterioration in heart function early. Scientists think that one of the causes of heart disease in diabetes is that fat builds up in the heart, stopping it from filling and pumping properly, but this needs to be confirmed in larger numbers of people. In this project, the fellow will assess the hearts of 150 people with type 2 diabetes with no signs of heart failure. They will all have a series of tests, including MRI scans, heart ultrasound scans, exercise testing and blood tests. The fellow will perform the same tests in people without diabetes and look for differences between the two groups. They will work out which scanning methods detect early heart dysfunction best and will look for ‘biomarkers’ that flag the condition. This study will identify what abnormal changes happen in the heart in diabetes, and how these changes can progress to heart failure. It may reveal new targets to prevent or treat heart failure in people with diabetes.
Project details
| Grant amount | £289,326 |
|---|---|
| Grant type | Fellowships |
| Application type | Clinical Research Training Fellowship |
| Start Date | 01 August 2017 |
| Duration | 3 years |
| Reference | FS/16/47/32190 |
| Status | In Progress |
