Predicting sudden arrhythmic death: Electrophysiological phenotyping to define the clinical signatures of risk in the inherited cardiac conditions
Dr Fu Siong Ng is studying why some people with an inherited heart condition are at greater risk of dying suddenly than others. Despite advances in genetic research, it is a challenge for doctors to predict which people with inherited heart conditions are likely to develop a heart rhythm abnormality or die suddenly. Dr Ng believes that changes in the electrical properties of the heart in response to external stresses, such as emotional stress or exercise, may help us detect people at greatest risk. In this project, people with inherited heart conditions such as Brugada Syndrome or hypertrophic cardiomyopathy will undergo several tests mimicking types of physiological stress. Dr Ng will record the changes in the heart’s electrical properties while they are experiencing these stresses and will look for patterns that indicate who is at risk. This research will improve our understanding of inherited heart conditions. It aims to discover new ways to detect people with inherited heart conditions at risk of developing lethal heart rhythm disturbances. This will help doctors provide more personalised, tailored treatments for those people.
Project details
| Grant amount | £254,099 |
|---|---|
| Grant type | Project Grants |
| Application type | Project Grant |
| Start Date | 01 April 2015 |
| Duration | 2 years, 6 months |
| Reference | PG/15/20/31339 |
| Status | Complete |
