Platelet heterogeneity in cardiovascular disease: a proteomic approach (Dr Abhishek Joshi)
Platelets are tiny cells, which are vital for blood clotting – they stick together at the site of injury and form a plug to prevent further blood loss. However some people have larger platelets than others, which increases their risk of having a heart attack. This is because when platelets bunch together and form a blood clot inside a blood vessel, they can slow or completely block the flow of blood to the heart, resulting in a heart attack. Professor Manuel Mayr from King's College London is supervising a BHF-funded fellow to explore the molecular differences in platelets of different sizes. He will compare the changes in the size of platelets with the changes in proteins and other molecules to determine the mechanisms that alter platelet size. He will then use these indicators, known as biomarkers, to predict the risk of heart and circulatory disease. Through his research, Professor Mayr also aims to help devise blood tests to identify people who are at risk of heart attacks.
Project details
| Grant amount | £256,003 |
|---|---|
| Grant type | Fellowships |
| Application type | Clinical Research Training Fellowship |
| Start Date | 01 July 2016 |
| Duration | 3 years |
| Reference | FS/16/32/32184 |
| Status | In Progress |
